Hussein M Dashti*1, Yousef Y Bo-Abbas2, Sami K Asfar1, Abdulla I Behbahani1, Mousa A Khoursheed1, Hilal M Al-Sayer1, Nagi S Al-Zaid3. 1Dept of Surgery, Fac of Med, Kuwait Univ, Kuwait, Kuwait, Kuwait; 2Dept of Med, Fac of Med, Kuwait Univ, Kuwait, Kuwait, Kuwait; 3Deaprtment of Physiology, Fac of Med, Kuwait Univ, Kuwait, Kuwait, Kuwait.
To determine the long-term effects of ketogenic diet (consisting of 30 gms carbohydrate, 1gm/kg body weight protein, 20% polysaturated, 80% polyunsaturated and monounsaturated fat) in obese patients following the administration for a period of twelve weeks.
In this study sixty-three obese patients (body mass index > 30kg/m2) with a high glucose and cholesterol level were selected. Female: male ratio was 2:1. The fasting blood sugar, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, Na+, K+, urea, uric acid and creatinine levels of these patients were determined before and after the administration of the ketogenic diet. Changes in these parameters were monitored at weekly interval for twelve weeks.
There was a significant reduction in all the parameters examined (p <0.001), except in the level of Na+, K+, and creatinine, while the level of HDL-cholesterol significantly increased. The level of urea and uric acid increased transiently during the 2nd and the 3rd week and returned to normal level during the 4th week. These levels remained constant from 4th to the 12th week. Interestingly, there was a significant reduction in body weight (99 +/- 2.8 to 80 + 3.0 kg). The level of triglycerides (2.74 +/-1.2 to 1.2 +/- 0.5 mmol/L), cholesterol (5.4 +/- 0.14 to 4.72 +/- 0.28 mmol/L), LDL (4.13 +/- 0.14 to 3.1 + 0.12 mmol/L) and glucose (7.7 +/- 0.5 to 5.2 +/- 0.43 mmol/L) also significantly decreased. The level of HDL showed a significant increase from 1.08 +/- 1.01 to 1.3 +/- 0.1 mmol/L. In conclusion: - Ketogenic diet acts as a natural therapy for weight reduction in obese patients. It significantly reduced the level of triglycerides, total cholesterol, LDL-cholesterol and glucose whereas the level of HDL increased in these patients. The side effect of other drugs commonly used for the reduction of body weight in such patients is not observed in patients who were on Ketogenic diet. These results indicate that the administration of ketogenic diet for relatively long period is safe to follow. "
Leniwy Kain
"Tamten frajer z drugiej strony to odwieczny wróg ,rozkaz padł rzucasz granat, on juz jest bez nóg.Miał 20 lat jak ty i chciał rzucić też,ty dostaniesz wielki order z niego tryska krew"