Pierwsze, co mnie zainteresowało ostatnio na temat acid-base equilibrium.
Metabolic and endocrine effects of metabolic
acidosis in humans
W skrócie: W linku znajdziecie badania na temat wpływu kwasowości na organizm człowieka. Ogółem, dowiedziono, iż kwasica powoduje: straty azotu, wpływa negatywnie na metabolizm białek, obniża stężenie IGF-1, negatywnie na stężenie T3 oraz T4, podwyższa stężenie glikokortykoidów oraz wpływa negatywnie na gospodarkę wapniem.
http://www.smw.ch/docs/pdf200x/2001/09/smw-09666.pdf
Alkaline diets favor lean tissue mass in older adults
Badania objęły grupę 384 ludzi starszych wieku +65 lata. Celem badania było stwierdzenie, czy dieta alkaliczna wpływa pozytywnie na zachowanie masy mięśniowej. Podsumowanie badania: Zwiększona podaż potasu z diety, z warzyw oraz owoców może służyć ochronie masy mięśniowej u ludzi starszych wiekiem.
http://www.ajcn.org/cgi/content/full/87/3/662
Potassium Bicarbonate Reduces Urinary Nitrogen Excretion in Postmenopausal Women
Previously we demonstrated that low grade chronic metabolic acidosis exists normally in humans eating ordinary diets that yield normal net rates of endogenous acid production (EAP), and that the degree of acidosis increases with age. We hypothesize that such diet-dependent and age-amplifying low grade metabolic acidosis contributes to the decline in skeletal muscle mass that occurs normally with aging. This hypothesis is based on the reported finding that chronic metabolic acidosis induces muscle protein breakdown, and that correction of acidosis reverses the effect. Accordingly, in 14 healthy postmenopausal women residing in a General Clinical Research Center and eating a constant diet yielding a normal EAP rate, we tested whether correcting their "physiological" acidosis with orally administered potassium bicarbonate (KHCO3; 60-120 mmol/day for 18 days) reduces their urinary nitrogen loss. KHCO3 reduced EAP to nearly zero, significantly reduced the blood hydrogen ion concentration (P < 0.001), and increased the plasma bicarbonate concentration (P < 0.001), indicating that pre-KHCO3, diet-dependent EAP was significantly perturbing systemic acid-base equilibrium, causing a low grade metabolic acidosis. Urinary ammonia nitrogen, urea nitrogen, and total nitrogen levels significantly decreased. The cumulative reduction in nitrogen excretion was 14.1 ± 12.3 g (P < 0.001). Renal creatinine clearance and urine volume remained unchanged. We conclude that in postmenopausal women, neutralization of diet-induced EAP with KHCO3 corrects their preexisting diet-dependent low grade metabolic acidosis and significantly reduces their urinary nitrogen wasting. The magnitude of the KHCO3-induced nitrogen-sparing effect is potentially sufficient to both prevent continuing age-related loss of muscle mass and restore previously accrued deficits.
W skrócie: Badano wpływ suplementacji potasem na równowagę kwasowo-zasadową. Wynik - pozytywny. Suplementacja potasem ma wpływ alkaliczny.
http://jcem.endojournals.org/cgi/content/full/82/1/254
Acid-Base Status Affects Renal Magnesium Losses in Healthy, Elderly Persons
Magnesium and calcium deficiency in humans is related to a number of pathological phenomena such as arrhythmia, osteoporosis, migraine, and fatal myocardial infarction. Clinically established metabolic acidosis induces renal losses of calcium. In normal subjects, even moderate increases in net endogenous acid production (NEAP) impair renal calcium reabsorption but no information is available whether this also influences renal magnesium handling. The aim of the study was to examine the relation between NEAP and renal magnesium excretion in healthy, free-living, elderly subjects. The subjects (age 64 ± 4.7 y, n = 85) were randomly selected from the population register in Gothenburg (Sweden). Magnesium, calcium, and potassium were measured in 24-h urine samples and NEAP was quantified as renal net acid excretion (NAE). NAE was positively correlated with excretions of magnesium (R2 = 0.27, P < 0.0001) and calcium (R2 = 0.30, P < 0.0001) but not potassium. When 24-h urinary magnesium excretion was adjusted for 24-h urinary potassium excretion, a biomarker for dietary potassium intake, the association between magnesium excretion and NAE remained significant (R2 = 0.21, P < 0.0001). The significant association between potassium-adjusted magnesiuria and NAE suggests that the acid-base status affects renal magnesium losses, irrespectively of magnesium intake. Magnesium deficiency could thus, apart from an insufficient intake, partly be caused by the acid load in the body.
http://jn.nutrition.org/cgi/content/full/136/9/2374
Glucocorticoids and acidosis stimulae protein and amino acids catabolism in vivo
http://www.nature.com/ki/journal/v49/n3/pdf/ki199696a.pdf
Dużo więcej w referencjach.
Tabela pral:
http://www.thepaleodiet.com/nutritional_tools/acid.shtml
Na forum o równowadze kwasowo-zasadowej można przeczytać miej inaczej tutaj:
[https://www.sfd.pl/temat319905] by Mateo 1983
[https://www.sfd.pl/temat344643] by qazar
Zmieniony przez - Skalar. w dniu 2009-08-02 11:34:58