bimbam73
Cell Metab. 2011 Jun 8;13(6):627-38.
mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and *****itating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.
Copyright © 2011 Elsevier Inc. All rights reserved.
Kwas ursolowy ( zawarty np w skorkach jablek) chroni przed urata miesni a nawet przyczynia sie do ich znaczacego wzrostu.
Ale zadaje sie ze pisze ze na razie tylko u myszy to stwierdzono. Bardzo swieza sprawa.
Zmieniony przez - bimbam73 w dniu 2011-06-08 10:41:32
mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass.
Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM.
Source
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA; Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA.
Abstract
Skeletal muscle atrophy is a common and *****itating condition that lacks a pharmacologic therapy. To develop a potential therapy, we identified 63 mRNAs that were regulated by fasting in both human and mouse muscle, and 29 mRNAs that were regulated by both fasting and spinal cord injury in human muscle. We used these two unbiased mRNA expression signatures of muscle atrophy to query the Connectivity Map, which singled out ursolic acid as a compound whose signature was opposite to those of atrophy-inducing stresses. A natural compound enriched in apples, ursolic acid reduced muscle atrophy and stimulated muscle hypertrophy in mice. It did so by enhancing skeletal muscle insulin/IGF-I signaling and inhibiting atrophy-associated skeletal muscle mRNA expression. Importantly, ursolic acid's effects on muscle were accompanied by reductions in adiposity, fasting blood glucose, and plasma cholesterol and triglycerides. These findings identify a potential therapy for muscle atrophy and perhaps other metabolic diseases.
Copyright © 2011 Elsevier Inc. All rights reserved.
Kwas ursolowy ( zawarty np w skorkach jablek) chroni przed urata miesni a nawet przyczynia sie do ich znaczacego wzrostu.
Ale zadaje sie ze pisze ze na razie tylko u myszy to stwierdzono. Bardzo swieza sprawa.
Zmieniony przez - bimbam73 w dniu 2011-06-08 10:41:32
Krzysztof Piekarz
Sebeky
faftaq
