LETROZOL vs EXEMESTANE

mam pytanie, który według was jest lepszym blokerem estrogenów ?
tzn. który bardziej by dorzucić do metki,teścia
na papierze exemestane wychodzi dobrze,{ nie jedzie po wątrobie} okres półtrwania 27h

letrozol jest najsilniejszym jaki istnieje

Dokładnie Femka jest najsilniejszym inhibitorem aromatazy ;)

Anastrozol jest chyba jeszcze lepszy

EDIT - okej, jest słabszy ale ma bardzo ważną zaletę:

"To understand why Aromasin may be useful in conjunction with Nolvadex while both Letro and A-dex suffer reduced effectiveness, we’ll need to first understand the differences between a Type-I and Type-II Aromatase Inhibitor. Type I inhibitors (like Aromasin) are actually steroidal compounds, while typeII inhibitors (like Letro and A-dex) are non-steroidal drugs. Hence, androgenic side effects are very possible with Type-I AIs, and they should probably be avoided by women. Of course, there are some similarities between the two types of AIs…both type I & type II AIs mimic normalsubstrates (essentially androgens), allowing them to compete with the substrate for accessto the binding site on the aromatase enzyme. After this binding, thenext step is where things differ greatly for the two different types of AI’s. In the case of a type-I AI, the noncompetitive inhibitorwill bind, and the enzyme initiates a sequence of hydroxylation; this hydroxylation produces an unbreakable covalent bond betweenthe inhibitor and the enzyme protein. Now, enzyme activity is permanently blocked; even if all unattached inhibitor is removed.Aromatase enzyme activity can only be restored by new enzyme synthesis. Now, on the other hand, competitive inhibitors, called type II AI’s, reversibly bind to the active enzymesite, and one of two things can happen: 1.) either no enzyme activity is triggered or 2.) the enzyme is somehow triggered withouteffect. The type II inhibitor can now actually disassociate from the binding site, eventually allowing renewed competition between the inhibitor and the substratefor binding to the site. This means that the effectiveness of competitive aromatase inhibitors depends on the relative concentrations and affinitiesof both the inhibitor and the substrate, while this is not so for noncompetitive inhibitors. Aromasin is a type-I inhibitor, meaning that once it has done its job, and deactivated the aromatase enzyme, we don’t need it anymore. Letrozole and Arimidex actually need to remain present to continue their effects. This is possibly why Nolvadex does not alter the pharmacokinetics of Aromasin (11)."


W skrócie - może być efektywnie wykożystywany przy PCT w odróżnieniu od exemestanu i letrozolu.


Zmieniony przez - kat1340 w dniu 2012-06-25 22:23:10

dymek w jakim celu zbicie estro___estrogen jest bardzo istotny w organizmie a zwłaszcza w trakcie cyklu___jak boisz się gino to miej pod ręką nolve i daj w razie potrzeby. włożysz ferme to będziesz miał choojowe samopoczucie

pozatym blokery to nolva lub clom, a ferma ari to już IA

Zmieniony przez - 8x8 w dniu 2012-06-25 23:05:57